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Title: Real-time measurement of nano-particle size using differential optical phase detection
Authors: Lin, Feng
Wu, Xingkun
Li, Qing
Huang, He
Keywords: Particle Size
Phase Measurement
DRNTU::Engineering::Computer science and engineering
Issue Date: 2017
Source: Li, Q., Huang, H., Lin, F., & Wu, X. (2017). Real-time measurement of nano-particle size using differential optical phase detection. Chinese Optics Letters, 15(12), 120602-. doi:10.3788/COL201715.120602
Series/Report no.: Chinese Optics Letters
Abstract: We demonstrate a size sensing technique for nano-particles using optical differential phase measurement by a dual fiber interferometer through phase-generated carrier (PGC) demodulation. Nano-particle diameters are obtained from the differential phase shift as a result of adding an optical scattering perturbation into two-beam interference. Polystyrene nano-particles with diameters from 200 to 900 nm in a microfluidic channel are detected using this technique to acquire real-time particle diameters. Compared with amplitude sensing with over 10 mW of laser irradiance, particle sizing by PGC phase sensing can be achieved at a laser power as low as 1.18 mW. We further analyze major sources of noise in order to improve the limits of detection. This sensing technique may find a broad range of applications from the real-time selection of biological cell samples to rare cell detection in blood samples for early cancer screening.
ISSN: 1671-7694
DOI: 10.3788/COL201715.120602
Rights: © 2017 Chinese Optics Letters. This paper was published in Chinese Optics Letters and is made available as an electronic reprint (preprint) with permission of Chinese Optics Letters. The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCSE Journal Articles

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