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Title: Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy
Authors: Fondi, Klemens
Bata, Ahmed M.
Luft, Nikolaus
Witkowska, Katarzyna J.
Werkmeister, René M.
Schmidl, Doreen
Bolz, Matthias
Schmetterer, Leopold
Garhöfer, Gerhard
Keywords: DRNTU::Science::Medicine
Issue Date: 2018
Source: Fondi, K., Bata, A. M., Luft, N., Witkowska, K. J., Werkmeister, R. M., Schmidl, D., . . . Garhöfer, G. (2018). Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy. PLOS ONE, 13(11), e0207525-. doi: 10.1371/journal.pone.0207525
Series/Report no.: PLOS ONE
Abstract: Purpose: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation. Methods: Twenty healthy subjects were included in this cross sectional study. A commercial LSFG instrument was used to measure blood flow at the ONH as well as in retinal vessels before and during stimulation with flickering light. Mean blur rate (MBR), a measure of relative blood flow velocity, was obtained for the ONH and relative flow volume (RFV) a measure of relative blood flow of the respective retinal vessels. Results: Stimulation with flicker light increased ONH MBR by +17.5%±6.6% (p<0.01). In retinal arteries, flicker stimulation led an increase of +23.8±10.0% (p<0.05) in total RFV. For retinal veins, an increase of +23.1%±11.0 (p<0.05) in total RFV was observed during stimulation. A higher response was observed in nasal RFV compared to temporal RFV in retinal arteries (nasal: +28.9%±20.0%; temporal: +20.4%±17.6%, p<0.05) and veins (nasal: +28.3%±19.6%; temporal +17.8%±18.9%, p<0.05). Conclusion: As shown previously with other techniques, flicker stimulation leads to an increase in retinal and optic nerve head blood flow. Our results indicate that LSFG is an appropriate method for the quantification of retinal and ONH blood flow during visual stimulation and may be used as a non-invasive, easy to use tool to assess neuro-vascular coupling in humans.
DOI: 10.1371/journal.pone.0207525
Rights: © 2018 Fondi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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