Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88983
Title: Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles
Authors: Upputuri, Paul Kumar
Yang, Cangjie
Huang, Shuo
Wang, Kai
Wang, Mingfeng
Pramanik, Manojit
Keywords: Photoacoustic Tomography
DRNTU::Engineering::Bioengineering
Second Near-infrared Window
Issue Date: 2018
Source: Upputuri, P. K., Yang, C., Huang, S., Wang, K., Wang, M., & Pramanik, M. (2018). Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles. Journal of Biomedical Optics, 24(03), 031002-. doi:10.1117/1.JBO.24.3.031002
Series/Report no.: Journal of Biomedical Optics
Abstract: Photoacoustic imaging (PAI) is a fast growing deep-tissue imaging modality. However, light scattering and absorption in biological tissues limit imaging depth. Short near-infrared wavelengths (650 to 950 nm) are widely used for PAI. Using longer near-infrared wavelengths reduces scattering. We demonstrate deep-tissue contrast-enhanced in vivo photoacoustic imaging at a wavelength of 1064 nm. An ultranarrow bandgap semiconducting polymer poly (thienoisoindigo-alt-diketopyrrolopyrrole) (denoted as PIGD) is designed and demonstrated for imaging at 1064 nm. By embedding colloidal nanoparticles (NPs) of PIGD in chicken-breast tissue, an imaging depth of ∼5  cm is achieved. Intravenous injection of PIGD NPs in living rats showed brain vascular images with ∼2 times higher contrast compared with the brain vascular images without any contrast agent. Thus, PIGD NPs as an NIR-II contrast agent opens new opportunities for both preclinical and clinical imaging of deep tissues with enhanced contrast.
URI: https://hdl.handle.net/10356/88983
http://hdl.handle.net/10220/46055
ISSN: 1083-3668
DOI: 10.1117/1.JBO.24.3.031002
Rights: © 2018 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The published version is available at: [http://dx.doi.org/10.1117/1.JBO.24.3.031002]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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