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Title: On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity
Authors: Gao, Feng
Djordjevic, Ivan
Pokholenko, Oleksandr
Zhang, Haobo
Zhang, Junying
Steele, Terry W. J.
Keywords: Dendrimers
Issue Date: 2018
Source: Gao, F., Djordjevic, I., Pokholenko, O., Zhang, H., Zhang, J., & Steele, T. W. J. (2018). On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity. Molecules, 23(4), 796-.
Series/Report no.: Molecules
Abstract: Tissue adhesives based on polyamidoamine (PAMAM) dendrimer, grafted with UV-sensitive aryldiazirine (PAMAM-g-diazirine) are promising new candidates for light active adhesion on soft tissues. Diazirine carbene precursors form interfacial and intermolecular covalent crosslinks with tissues after UV light activation that requires no premixing or inclusion of free radical initiators. However, primary amines on the PAMAM dendrimer surface present a potential risk due to their cytotoxic and immunological effects. PAMAM-g-diazirine formulations with cationic pendant amines converted into neutral amide groups were evaluated. In vitro toxicity is reduced by an order of magnitude upon amine capping while retaining bioadhesive properties. The in vivo immunological response to PAMAM-g-diazirine formulations was found to be optimal in comparison to standard poly(lactic-co-glycolic acid) (PLGA) thin films.
ISSN: 1420-3049
DOI: 10.3390/molecules23040796
Rights: © 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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