Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89124
Title: Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
Authors: Chang, Hao
Duong, Phan Khanh
Than, Aung
Liu, Chenghao
Cheung, Gemmy Chui Ming
Xu, Chenjie
Wang, Xiaomeng
Chen, Peng
Keywords: DRNTU::Engineering::Chemical engineering
Microneedles
DC101
Issue Date: 2018
Source: Than, A., Liu, C., Chang, H., Duong, P. K., Cheung, G. C. M., Xu, C., . . . Chen, P. (2018). Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications, 9(1), 4433-. doi:10.1038/s41467-018-06981-w
Series/Report no.: Nature Communications
Abstract: Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can penetrate the ocular surface tissue, and serve as implanted micro-reservoirs for controlled drug delivery. The biphasic drug release kinetics enabled by the double-layered micro-reservoirs largely enhances therapeutic efficacy. Using corneal neovascularization as the disease model, we show that delivery of an anti-angiogenic monoclonal antibody (DC101) by such eye patch produces ~90% reduction of neovascular area. Furthermore, quick release of an anti-inflammatory compound (diclofenac) followed by a sustained release of DC101 provides synergistic therapeutic outcome. The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases.
URI: https://hdl.handle.net/10356/89124
http://hdl.handle.net/10220/47673
DOI: 10.1038/s41467-018-06981-w
Rights: © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
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