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dc.contributor.authorHernández-Pérez, Jesúsen
dc.contributor.authorSerra, Aidaen
dc.contributor.authorSze, Siu Kwanen
dc.contributor.authorConway, Patricia Lynneen
dc.contributor.authorSchlundt, Jørgenen
dc.contributor.authorBenavides, Jorgeen
dc.identifier.citationHernández-Pérez, J., Serra, A., Sze, S. K., Conway, P. L., Schlundt, J., & Benavides, J. (2018). Identification of arenin, a novel Kunitz-like polypeptide from the skin secretions of Dryophytes arenicolor. International Journal of Molecular Sciences, 19(11), 3644-. doi: 10.3390/ijms19113644en
dc.description.abstractAmphibian skin secretions are enriched with complex cocktails of bioactive molecules such as proteins, peptides, biogenic amines, alkaloids guanidine derivatives, steroids and other minor components spanning a wide spectrum of pharmacological actions exploited for centuries in folk medicine. This study presents evidence on the protein profile of the skin secretions of the canyon tree frog, Dryophytes arenicolor. At the same time, it presents the reverse-phase liquid chromatography isolation, mass spectrometry characterization and identification at mRNA level of a novel 58 amino acids Kunitz-like polypeptide from the skin secretions of Dryophytes arenicolor, arenin. Cell viability assays performed on HDFa, CaCo2 and MCF7 cells cultured with different concentrations of arenin showed a discrete effect at low concentrations (2, 4, 8 and 16 µg/mL) suggesting a multi-target interaction in a hormetic-like dose-response. Further work is required to investigate the mechanisms underlying the variable effect on cell viability produced by different concentrations of arenin.en
dc.format.extent19 p.en
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectDRNTU::Science::Biological sciencesen
dc.subjectSkin Secretionsen
dc.titleIdentification of arenin, a novel Kunitz-like polypeptide from the skin secretions of Dryophytes arenicoloren
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.researchNTU Food Technology Centreen
dc.description.versionPublished versionen
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