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Title: Multiple aperture synthetic optical coherence tomography for biological tissue imaging
Authors: Bo, En
Ge, Xin
Wang, Lulu
Wu, Xuan
Luo, Yuemei
Chen, Shufen
Chen, Si
Liang, Haitao
Ni, Guangming
Yu, Xiaojun
Liu, Linbo
Keywords: Medical And Biological Imaging
Optical Coherence Tomography
Issue Date: 2018
Source: Bo, E., Ge, X., Wang, L., Wu, X., Luo, Y., Chen, S., et al. (2018). Multiple aperture synthetic optical coherence tomography for biological tissue imaging. Optics Express, 26(2), 772-780.
Series/Report no.: Optics Express
Abstract: An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica 4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension.
DOI: 10.1364/OE.26.000772
Rights: © 2018 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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