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Title: Near-infrared light-mediated rare-earth nanocrystals: recent advances in improving photon conversion and alleviating the thermal effect
Authors: Lyu, Linna
Cheong, Haolun
Ai, Xiangzhao
Zhang, Wenmin
Li, Juan
Yang, HuangHao
Lin, Jun
Xing, Bengang
Keywords: Digital Storage
Issue Date: 2018
Source: Lyu, L., Cheong, H., Ai, X., Zhang, W., Li, J., Yang, H., . . . Xing, B. Near-infrared light-mediated rare-earth nanocrystals: recent advances in improving photon conversion and alleviating the thermal effect. NPG Asia Materials, 10, 685–702. doi:10.1038/s41427-018-0065-y
Series/Report no.: NPG Asia Materials
Abstract: With the rapid development of nanotechnology, the unique rare-earth lanthanide-doped upconversion nanocrystals (UCNs), which can convert tissue-penetrable near-infrared (NIR) photonic irradiation into ultraviolet, visible, and NIR emissions, have a significant potential in bioimaging, diagnosis, and therapy, as well as in photovoltaic systems and optical data storage. Despite the promising achievements made in the past decade, critical challenges associated with low upconversion efficiencies and the overheating effect induced by NIR laser-irradiation still remain in the biomedical fields. In high demand are more well-defined material design and unique structural modifications that are capable of solving these technical concerns and promoting such promising NIR light-mediated upconversion nanocrystals for their further application in the medical sciences. Recent advances in upconversion nanomaterials have witnessed a tremendous development towards enhancing their photon conversion efficiency, which provides great opportunities in expanding the potential of the UCNs in bioimaging diagnosis and anticancer therapy. Hence, this review is mainly focused on summarizing the fundamental principles and strategies that improve upconversion luminescence and the approaches to reduce the local thermal effect on the basis of a rational design of UCNs. In addition, the future perspectives in the development of UCNs for biomedical applications are also proposed.
ISSN: 1884-4049
DOI: 10.1038/s41427-018-0065-y
Rights: © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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