Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89304
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dc.contributor.authorZhou, Chaoen
dc.contributor.authorWu, Yangen
dc.contributor.authorThappeta, Kishore Reddy Venkataen
dc.contributor.authorSubramanian, Jo Thy Lachumyen
dc.contributor.authorPranantyo, Dickyen
dc.contributor.authorKang, En-Tangen
dc.contributor.authorDuan, Hongweien
dc.contributor.authorKline, Kimberly A.en
dc.contributor.authorChan-Park, Mary B.en
dc.date.accessioned2018-05-24T03:20:30Zen
dc.date.accessioned2019-12-06T17:22:26Z-
dc.date.available2018-05-24T03:20:30Zen
dc.date.available2019-12-06T17:22:26Z-
dc.date.issued2017en
dc.identifier.citationZhou, C., Wu, Y., Thappeta, K. R. V., Subramanian, J. T. L., Pranantyo, D., Kang, E.-T., et al. (2017). In vivo anti-biofilm and anti-bacterial non-leachable coating thermally polymerized on cylindrical catheter. ACS Applied Materials & Interfaces, 9(41), 36269-36280.en
dc.identifier.issn1944-8244en
dc.identifier.urihttps://hdl.handle.net/10356/89304-
dc.identifier.urihttp://hdl.handle.net/10220/44885en
dc.description.abstractCatheters are indispensable tools of modern medicine, but catheter-associated infection is a significant clinical problem, even when stringent sterile protocols are observed. When the bacteria colonize catheter surfaces, they tend to form biofilms making them hard to treat with conventional antibiotics. Hence, there is a great need for inherently antifouling and antibacterial catheters that prevent bacterial colonization. This paper reports the preparation of nonleachable antibiofilm and antibacterial cationic film coatings directly polymerized from actual tubular silicone catheter surfaces via the technique of supplemental activator and reducing agent surface-initiated atom-transfer radical polymerization (SARA SI-ATRP). Three cross-linked cationic coatings containing (3-acrylamidopropyl) trimethylammonium chloride (AMPTMA) or quaternized polyethylenimine methacrylate (Q-PEI-MA) together with a cross-linker (polyethylene glycol dimethacrylate, PEGDMA) were tested. The in vivo antibacterial and antibiofilm effect of these nonleachable covalently linked coatings (using a mouse catheter model) can be tuned to achieve 1.95 log (98.88%) reduction and 1.26 log (94.51%) reduction of clinically relevant pathogenic bacteria (specifically with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE)). Our good in vivo bactericidal killing results using the murine catheter-associated urinary tract infection (CAUTI) model show that SARA SI-ATRP grafting-from technique is a viable technique for making nonleachable antibiofilm coating even on "small" (0.30/0.64 mm inner/outer diameter) catheter.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent56 p.en
dc.language.isoenen
dc.relation.ispartofseriesACS Applied Materials & Interfacesen
dc.rights© 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acsami.7b07053].en
dc.subjectSARA SI-ATRPen
dc.subjectAntibiofilmen
dc.titleIn vivo anti-biofilm and anti-bacterial non-leachable coating thermally polymerized on cylindrical catheteren
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.researchCentre for Antimicrobial Bioengineeringen
dc.contributor.researchSingapore Centre for Environmental Life Sciences Engineeringen
dc.identifier.doihttp://dx.doi.org/10.1021/acsami.7b07053en
dc.description.versionAccepted versionen
item.grantfulltextopen-
item.fulltextWith Fulltext-
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