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Title: Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging
Authors: Wu, Xumeng
Tan, Yu Jia
Toh, Hui Ting
Nguyen, Lan Huong
Kho, Shu Hui
Chew, Sing Yian
Yoon, Ho Sup
Liu, Xue-Wei
Keywords: Carbohydrates
Issue Date: 2017
Source: Wu, X., Tan, Y. J., Toh, H. T., Nguyen, L. H., Kho, S. H., et al. (2017). Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging. Chemical Science, 8(5), 3980-3988.
Series/Report no.: Chemical Science
Abstract: Targeted bioimaging or chemotherapeutic drug delivery to achieve the desired therapeutic effects while minimizing side effects has attracted considerable research attention and remains a clinical challenge. Presented herein is a multi-component delivery system based on carbohydrate-functionalized gold nanoparticles conjugated with a fluorophore or prodrug. The system leverages active targeting based on carbohydrate–lectin interactions and release of the payload by biological thiols. Cell-type specific delivery of the activatable fluorophore was examined by confocal imaging on HepG2 cells, and displays distinct selectivity towards HepG2 cells over HeLa and NIH3T3 cells. The system was further developed into a drug delivery vehicle with camptothecin (CPT) as a model drug. It was demonstrated that the complex exhibits similar cytotoxicity to that of free CPT towards HepG2 cells, and is significantly less cytotoxic to normal HDF and NIH3T3 cells, indicating excellent specificity. The delivery vehicle itself exhibits excellent biocompatibility and offers an attractive strategy for cell-type specific delivery depending on the carbohydrates conjugated in the system.
ISSN: 2041-6520
DOI: 10.1039/C6SC05251G
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Chemical and Biomedical Engineering 
School of Biological Sciences 
School of Physical and Mathematical Sciences 
Rights: © 2017 The Royal Society of Chemistry. Open Access Article. Published on 30 March 2017. Downloaded on 23/05/2018 07:08:11. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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