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Title: The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting
Authors: Lee, Hyun
Jang, Tae-Sik
Song, Juha
Kim, Hyoun-Ee
Jung, Hyun-Do
Keywords: Porous Materials
Issue Date: 2017
Source: Lee, H., Jang, T.-S., Song, J., Kim, H.-E., & Jung, H.-D. (2017). The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting. Materials, 10(4), 367-.
Series/Report no.: Materials
Abstract: Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering.
ISSN: 1996-1944
DOI: 10.3390/ma10040367
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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