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dc.contributor.authorWang, Zhiminen
dc.contributor.authorUpputuri, Paul Kumaren
dc.contributor.authorZhen, Xuen
dc.contributor.authorZhang, Ruochongen
dc.contributor.authorJiang, Yuyanen
dc.contributor.authorAi, Xiangzhaoen
dc.contributor.authorZhang, Zhijunen
dc.contributor.authorHu, Mingen
dc.contributor.authorMeng, Zhenyuen
dc.contributor.authorLu, Yunpengen
dc.contributor.authorZheng, Yuanjingen
dc.contributor.authorPu, Kanyien
dc.contributor.authorPramanik, Manojiten
dc.contributor.authorXing, Bengangen
dc.identifier.citationWang, Z., Upputuri, P. K., Zhen, X., Zhang, R., Jiang, Y., Ai, X., ... Xing, B. (2019). pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging. Nano Research, 12(1), 49-55. doi:10.1007/s12274-018-2175-9en
dc.description.abstractThe emerging photoacoustic imaging (PAI), especially in the NIR window, offers reliable sensing for deep-penetration and high-resolution closing to clinical requirements. However, the contrast agents that are capable of specifically responding to the intricate biological environments, more importantly, indicate promising biodegradability and biocompatibility are still limited. Herein, we introduce a new class of pH-sensitive organic PA contrast agent working in the second near-infrared window (NIR-II, 960 - 1700 nm), which is derived from the self-assembled charge-transfer nanocomplex (CTN) by 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and its dication structure (TMB++). Such unique NIR-II-responsive CTN can specifically respond to pH change in the physiological range, allows noninvasive and sensitive visualization of the tumor acidic microenvironment (e.g. at pH 5) in mice with higher signal-to-noise ratio (SNR). Moreover, this organic CTN demonstrates the biodegradable feature in physiological condition (e.g. at pH 7.4), which provides the great biosafety without the concern of nanoparticles accumulation in vivo. These results clearly show the potential of TMB/TMB++-based CTN as a promising pH-activatable and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent13 p.en
dc.relation.ispartofseriesNano Researchen
dc.rights© 2019 Tsinghua University Press and Springer. This is the author created version of a work that has been peer reviewed and accepted for publication by Nano Research, Tsinghua University Press and Springer. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subjectSecond Near-infrared Windowen
dc.subjectCharge-transfer Nanocomplexen
dc.titlepH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imagingen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.description.versionAccepted versionen
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