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Title: pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging
Authors: Wang, Zhimin
Upputuri, Paul Kumar
Zhen, Xu
Zhang, Ruochong
Jiang, Yuyan
Ai, Xiangzhao
Zhang, Zhijun
Hu, Ming
Meng, Zhenyu
Lu, Yunpeng
Zheng, Yuanjing
Pu, Kanyi
Pramanik, Manojit
Xing, Bengang
Keywords: DRNTU::Science::Chemistry
Second Near-infrared Window
Charge-transfer Nanocomplex
Issue Date: 2019
Source: Wang, Z., Upputuri, P. K., Zhen, X., Zhang, R., Jiang, Y., Ai, X., ... Xing, B. (2019). pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging. Nano Research, 12(1), 49-55. doi:10.1007/s12274-018-2175-9
Series/Report no.: Nano Research
Abstract: The emerging photoacoustic imaging (PAI), especially in the NIR window, offers reliable sensing for deep-penetration and high-resolution closing to clinical requirements. However, the contrast agents that are capable of specifically responding to the intricate biological environments, more importantly, indicate promising biodegradability and biocompatibility are still limited. Herein, we introduce a new class of pH-sensitive organic PA contrast agent working in the second near-infrared window (NIR-II, 960 - 1700 nm), which is derived from the self-assembled charge-transfer nanocomplex (CTN) by 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and its dication structure (TMB++). Such unique NIR-II-responsive CTN can specifically respond to pH change in the physiological range, allows noninvasive and sensitive visualization of the tumor acidic microenvironment (e.g. at pH 5) in mice with higher signal-to-noise ratio (SNR). Moreover, this organic CTN demonstrates the biodegradable feature in physiological condition (e.g. at pH 7.4), which provides the great biosafety without the concern of nanoparticles accumulation in vivo. These results clearly show the potential of TMB/TMB++-based CTN as a promising pH-activatable and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.
ISSN: 1998-0124
DOI: 10.1007/s12274-018-2175-9
Schools: School of Electrical and Electronic Engineering 
School of Physical and Mathematical Sciences 
School of Chemical and Biomedical Engineering 
Rights: © 2019 Tsinghua University Press and Springer. This is the author created version of a work that has been peer reviewed and accepted for publication by Nano Research, Tsinghua University Press and Springer. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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