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Title: Biosensing with the singular phase of an ultrathin metal-dielectric nanophotonic cavity
Authors: Sreekanth, Kandammathe Valiyaveedu
Sreejith, Sivaramapanicker
Han, Song
Mishra, Amita
Chen, Xiaoxuan
Sun, Handong
Lim, Chwee Teck
Singh, Ranjan
Keywords: Biosensing
Issue Date: 2018
Source: Sreekanth, K. V., Sreejith, S., Han, S., Mishra, A., Chen, X., Sun, H., et al. (2018). Biosensing with the singular phase of an ultrathin metal-dielectric nanophotonic cavity. Nature Communications, 9, 369-.
Series/Report no.: Nature Communications
Abstract: The concept of point of darkness has received much attention for biosensing based on phase-sensitive detection and perfect absorption of light. The maximum phase change is possible at the point of darkness where the reflection is almost zero. To date, this has been experimentally realized using different material systems through the concept of topological darkness. However, complex nanopatterning techniques are required to realize topological darkness. Here, we report an approach to realize perfect absorption and extreme phase singularity using a simple metal-dielectric multilayer thin-film stack. The multilayer stack works on the principle of an asymmetric Fabry–Perot cavity and shows an abrupt phase change at the reflectionless point due to the presence of a highly absorbing ultrathin film of germanium in the stack. In the proof-of-concept phase-sensitive biosensing experiments, we functionalize the film surface with an ultrathin layer of biotin-thiol to capture streptavidin at a low concentration of 1 pM.
DOI: 10.1038/s41467-018-02860-6
DOI (Related Dataset): 10.21979/N9/127YJV
Rights: © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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