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|Title:||Light-driven liquid metal nanotransformers for biomedical theranostics||Authors:||Chechetka, Svetlana A.
|Issue Date:||2017||Source:||Chechetka, S. A., Yu, Y., Zhen, X., Pramanik, M., Pu, K., & Miyako, E. (2017). Light-driven liquid metal nanotransformers for biomedical theranostics. Nature Communications, 8, 15432-.||Series/Report no.:||Nature Communications||Abstract:||Room temperature liquid metals (LMs) represent a class of emerging multifunctional materials with attractive novel properties. Here, we show that photopolymerized LMs present a unique nanoscale capsule structure characterized by high water dispersibility and low toxicity. We also demonstrate that the LM nanocapsule generates heat and reactive oxygen species under biologically neutral near-infrared (NIR) laser irradiation. Concomitantly, NIR laser exposure induces a transformation in LM shape, destruction of the nanocapsules, contactless controlled release of the loaded drugs, optical manipulations of a microfluidic blood vessel model and spatiotemporal targeted marking for X-ray-enhanced imaging in biological organs and a living mouse. By exploiting the physicochemical properties of LMs, we achieve effective cancer cell elimination and control of intercellular calcium ion flux. In addition, LMs display a photoacoustic effect in living animals during NIR laser treatment, making this system a powerful tool for bioimaging.||URI:||https://hdl.handle.net/10356/89514
|ISSN:||2041-1723||DOI:||10.1038/ncomms15432||Rights:||© 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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