Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89519
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dc.contributor.authorReza, Musarrat Maishaen
dc.contributor.authorSubramaniyam, Nathiyaen
dc.contributor.authorSim, Chu Mingen
dc.contributor.authorGe, Xiaojiaen
dc.contributor.authorSathiakumar, Durgalakshmien
dc.contributor.authorMcFarlane, Craigen
dc.contributor.authorSharma, Mridulaen
dc.contributor.authorKambadur, Ravien
dc.date.accessioned2018-06-05T09:24:43Zen
dc.date.accessioned2019-12-06T17:27:30Z-
dc.date.available2018-06-05T09:24:43Zen
dc.date.available2019-12-06T17:27:30Z-
dc.date.issued2017en
dc.identifier.citationReza, M. M., Subramaniyam, N., Sim, C. M., Ge, X., Sathiakumar, D., McFarlane, C., et al. (2017). Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy. Nature Communications, 8(1), 1104-.en
dc.identifier.issn2041-1723en
dc.identifier.urihttps://hdl.handle.net/10356/89519-
dc.description.abstractExercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic differentiation and myoblast fusion via activation of IL6 signaling. Injection of irisin in mice induces significant hypertrophy and enhances grip strength of uninjured muscle. Following skeletal muscle injury, irisin injection improves regeneration and induces hypertrophy. The effects of irisin on hypertrophy are due to activation of satellite cells and enhanced protein synthesis. In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. These data suggest that irisin functions as a pro-myogenic factor in mice.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent17 p.en
dc.language.isoenen
dc.relation.ispartofseriesNature Communicationsen
dc.rights© 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectCell Differentiationen
dc.subjectPathophysiologyen
dc.titleIrisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1038/s41467-017-01131-0en
dc.description.versionPublished versionen
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