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dc.contributor.authorZolezzi, Francescaen
dc.contributor.authorHe, Jin-Shuen
dc.contributor.authorSubramaniam, Sharradaen
dc.contributor.authorNarang, Vipinen
dc.contributor.authorSrinivasan, Kandhadayaren
dc.contributor.authorSaunders, Sean P.en
dc.contributor.authorCarbajo, Danielen
dc.contributor.authorWen-Shan, Tsaoen
dc.contributor.authorHidayah Hamadee, Nuren
dc.contributor.authorLum, Josephineen
dc.contributor.authorLee, Andreaen
dc.contributor.authorChen, Jinmiaoen
dc.contributor.authorPoidinger, Michaelen
dc.contributor.authorLafaille, Juan J.en
dc.contributor.authorCurotto de Lafaille, Maria A.en
dc.identifier.citationHe, J.-S., Subramaniam, S., Narang, V., Srinivasan, K., Saunders, S. P., Carbajo, D., et al. (2017). IgG1 memory B cells keep the memory of IgE responses. Nature Communications, 8(1), 641-.en
dc.description.abstractThe unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80+CD73+ and CD80−CD73−, contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE. Furthermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate from rare CD80+CD73+ high affinity memory clones without undergoing further mutagenesis. By identifying the cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate, our findings provide fundamental insights into the pathogenesis of allergies, and on the mechanisms of antibody production in memory B cell responses.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent12 p.en
dc.relation.ispartofseriesNature Communicationsen
dc.rights© 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit licenses/by/4.0/.en
dc.subjectFlow Cytometryen
dc.subjectMicroarray Analysisen
dc.titleIgG1 memory B cells keep the memory of IgE responsesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionPublished versionen
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