Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89607
Title: The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
Authors: Zhai, Weiwei
Choo, Su-Pin
Khor, Chiea Chuen
Lim, Tony Kiat-Hon
Zhang, Tong
Phang, Su-Ting
Tiang, Zenia
Guan, Peiyong
Ng, Ming-Hwee
Lim, Jia Qi
Yao, Fei
Li, Zheng
Ng, Poh Yong
Yan, Jie
Goh, Brian K.
Chung, Alexander Yaw-Fui
Soon, Wendy Wei-Jia
Sung, Ken Wing-Kin
Foo, Roger Sik-Yin
Chow, Pierce Kah-Hoe
Keywords: Copy Number Variation
Cancer Genomics
Issue Date: 2017
Source: Zhai, W., Lim, T. K.-H., Zhang, T., Phang, S.-T., Tiang, Z., Guan, P., et al. (2017). The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma. Nature Communications, 8, 4565-.
Series/Report no.: Nature Communications
Abstract: Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversification. Unlike the variegated pattern found in colorectal cancers, a large proportion of HCC display a clear isolation-by-distance pattern where spatially closer sectors are genetically more similar. Two resected intra-hepatic metastases showed genetic divergence occurring before and after primary tumour diversification, respectively. Metastatic tumours had much higher variability than their primary tumours, suggesting that intra-hepatic metastasis is accompanied by rapid diversification at the distant location. The presence of co-existing mutations offers the possibility of drug repositioning for HCC treatment. Taken together, these insights into intra-tumour heterogeneity allow for a comprehensive understanding of the evolutionary trajectories of HCC and suggest novel avenues for personalized therapy.
URI: https://hdl.handle.net/10356/89607
http://hdl.handle.net/10220/44986
DOI: 10.1038/ncomms14565
Rights: © 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.