Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89682
Title: Topical delivery of senicapoc nanoliposomal formulation for ocular surface treatments
Authors: Phua, Jie Liang
Hou, Aihua
Lui, Yuan Siang
Bose, Tanima
Chandy, George Kanianthara
Tong, Louis
Venkatraman, Subbu
Huang, Yingying
Keywords: Liposomes
Senicapoc
DRNTU::Engineering::Materials
Issue Date: 2018
Source: Phua, J. L., Hou, A., Lui, Y. S., Bose, T., Chandy, G. K., Tong, L., . . . Huang, Y. (2018). Topical Delivery of Senicapoc Nanoliposomal Formulation for Ocular Surface Treatments. International Journal of Molecular Sciences, 19(10), 2977-. doi:10.3390/ijms19102977
Series/Report no.: International Journal of Molecular Sciences
Abstract: Topical ophthalmologic treatments have been facing great challenges with main limitations of low drug bioavailability, due to highly integrative defense mechanisms of the eye. This study rationally devised strategies to increase drug bioavailability by increasing ocular surface residence time of drug-loaded nanoliposomes dispersed within thermo-sensitive hydrogels (Pluronic F-127). Alternatively, we utilized sub-conjunctival injections as a depot technique to localize nanoliposomes. Senicapoc was encapsulated and sustainably released from free nanoliposomes and hydrogels formulations in vitro. Residence time increased up to 12-fold (60 min) with 24% hydrogel formulations, as compared to 5 min for free liposomes, which was observed in the eyes of Sprague-Dawley rats using fluorescence measurements. Pharmacokinetic results obtained from flushed tears, also showed that the hydrogels had greater drug retention capabilities to that of topical viscous solutions for up to 60 min. Senicapoc also remained quantifiable within sub-conjunctival tissues for up to 24 h post-injection.
URI: https://hdl.handle.net/10356/89682
http://hdl.handle.net/10220/46325
ISSN: 1661-6596
DOI: 10.3390/ijms19102977
Rights: © 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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