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dc.contributor.authorPhua, Jie Liangen
dc.contributor.authorHou, Aihuaen
dc.contributor.authorLui, Yuan Siangen
dc.contributor.authorBose, Tanimaen
dc.contributor.authorChandy, George Kaniantharaen
dc.contributor.authorTong, Louisen
dc.contributor.authorVenkatraman, Subbuen
dc.contributor.authorHuang, Yingyingen
dc.identifier.citationPhua, J. L., Hou, A., Lui, Y. S., Bose, T., Chandy, G. K., Tong, L., . . . Huang, Y. (2018). Topical Delivery of Senicapoc Nanoliposomal Formulation for Ocular Surface Treatments. International Journal of Molecular Sciences, 19(10), 2977-. doi:10.3390/ijms19102977en
dc.description.abstractTopical ophthalmologic treatments have been facing great challenges with main limitations of low drug bioavailability, due to highly integrative defense mechanisms of the eye. This study rationally devised strategies to increase drug bioavailability by increasing ocular surface residence time of drug-loaded nanoliposomes dispersed within thermo-sensitive hydrogels (Pluronic F-127). Alternatively, we utilized sub-conjunctival injections as a depot technique to localize nanoliposomes. Senicapoc was encapsulated and sustainably released from free nanoliposomes and hydrogels formulations in vitro. Residence time increased up to 12-fold (60 min) with 24% hydrogel formulations, as compared to 5 min for free liposomes, which was observed in the eyes of Sprague-Dawley rats using fluorescence measurements. Pharmacokinetic results obtained from flushed tears, also showed that the hydrogels had greater drug retention capabilities to that of topical viscous solutions for up to 60 min. Senicapoc also remained quantifiable within sub-conjunctival tissues for up to 24 h post-injection.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent17 p.en
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.titleTopical delivery of senicapoc nanoliposomal formulation for ocular surface treatmentsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.description.versionPublished versionen
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