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Title: Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore
Authors: Xu, Chuanhui
Pang, Junxiong
Hsu, Jung Pu
Leo, Yee Sin
Lye, David Chien Boon
Keywords: DRNTU::Science::Medicine
Clinical Features
Dengue Severity
Issue Date: 2018
Source: Xu, C., Pang, J., Hsu, J. P., Leo, Y. S., & Lye, D. C. B. (2018). Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore. PLOS ONE, 13(8), e0201441-. doi:10.1371/journal.pone.0201441
Series/Report no.: PLOS ONE
Abstract: Dengue is endemic in Singapore but not China. We compared clinical features and disease severity of dengue between local and migrant Chinese, most of whom were construction workers, in Singapore. A retrospective study with all hospitalized dengue patients from 2005 to 2008 were performed, including 2609 local and 1195 migrant Chinese. Compared with local Chinese, migrant Chinese were younger. There were more males, but fewer had comorbidities. Migrant Chinese had more headache, eye pain, nausea and myalgia. They had significantly lower median leukocyte count, ALT and AST, and higher platelet count nadir. Among warning signs, migrant Chinese had significantly less persistent vomiting, clinical fluid accumulation, hepatomegaly, hematocrit rise with rapid platelet drop, and more mucosal bleeding. Adjusted for age, gender and comorbidities, migrant Chinese were significantly at higher risk of dengue hemorrhagic fever (DHF) (adjusted odds ratio [aOR]: 1.20, 95% confidence interval [CI]: 1.03–1.41) and dengue shock syndrome (aOR: 1.49, 95% CI: 1.06–2.10), and had longer hospitalization (β coefficient value: 0.27, 95%CI: 0.09–0.44, p = 0.003). There was 1 death among migrant Chinese and 2 deaths among local Chinese. We documented differences in clinical and laboratory features, and dengue severity between local and migrant Chinese in Singapore. Migrant Chinese may need more medical attention given higher risk of DHF.
DOI: 10.1371/journal.pone.0201441
Rights: © 2018 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles


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