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Title: Bioengineering of metal-organic frameworks for nanomedicine
Authors: Liu, Yuan
Zhao, Yanli
Chen, Xiaoyuan
Keywords: Metal-organic Frameworks
Drug Delivery
Issue Date: 2019
Source: Liu, Y., Zhao, Y., & Chen, X. (2019). Bioengineering of Metal-organic Frameworks for Nanomedicine. Theranostics, 9(11), 3122-3133. doi:10.7150/thno.31918
Series/Report no.: Theranostics
Abstract: Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.
DOI: 10.7150/thno.31918
Rights: © 2019 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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