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Title: Capturing the fantastic voyage of monocytes through time and space
Authors: Teh, Ye Chean
Ding, Jeak Ling
Ng, Lai Guan
Chong, Shu Zhen
Keywords: Marginal Pool
Science::Biological sciences
Issue Date: 2019
Source: Teh, Y. C., Ding, J. L., Ng, L. G., & Chong, S. Z. (2019). Capturing the Fantastic Voyage of Monocytes Through Time and Space. Frontiers in Immunology, 10, 834-. doi:10.3389/fimmu.2019.00834
Series/Report no.: Frontiers in Immunology
Abstract: Monocytes are a subset of cells that are categorized together with dendritic cells (DCs) and macrophages in the mononuclear phagocyte system (MPS). Despite sharing several phenotypic and functional characteristics with MPS cells, monocytes are unique cells with the ability to function as both precursor and effector cells in their own right. Before the development of hematopoietic stem cells (HSCs) in utero, monocytes are derived from erythro-myeloid precursors (EMPs) in the fetal liver that are important for populating the majority of tissue resident macrophages. After birth, monocytes arise from bone marrow (BM)-derived HSCs and are released into the circulation upon their maturation, where they survey peripheral tissues and maintain endothelial integrity. Upon sensing of microbial breaches or inflammatory stimuli, monocytes migrate into tissues where their plasticity allows them to differentiate into cells that resemble macrophages or DCs according to the environmental niche. Alternatively, they may also migrate into tissues in the absence of inflammation and remain in an undifferentiated state where they perform homeostatic roles. As monocytes are typically on the move, the availability of intravital imaging approaches has provided further insights into their trafficking patterns in distinct tissue compartments. In this review, we outline the importance of understanding their functional behavior in the context of tissue compartments, and how these studies may contribute towards improved vaccine and future therapeutic strategies.
DOI: 10.3389/fimmu.2019.00834
Rights: © 2019 Teh, Ding, Ng and Chong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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