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Title: Precise cell behaviors manipulation through light-responsive nano-regulators : recent advance and perspective
Authors: Thang, Do Cong
Wang, Zhimin
Lu, Xiaoling
Xing, Bengang
Keywords: Nanoparticles
Near-infrared Light
Issue Date: 2019
Source: Thang, D. C., Wang, Z., Lu, X., & Xing, B. (2019). Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective. Theranostics, 9(11), 3308-3340. doi:10.7150/thno.33888
Series/Report no.: Theranostics
Abstract: Nanotechnology-assisted spatiotemporal manipulation of biological events holds great promise in advancing the practice of precision medicine in healthcare systems. The progress in internal and/or external stimuli-responsive nanoplatforms for highly specific cellular regulations and theranostic controls offer potential clinical translations of the revolutionized nanomedicine. To successfully implement this new paradigm, the emerging light-responsive nanoregulators with unparalleled precise cell functions manipulation have gained intensive attention, providing UV-Vis light-triggered photocleavage or photoisomerization studies, as well as near-infrared (NIR) light-mediated deep-tissue applications for stimulating cellular signal cascades and treatment of mortal diseases. This review discusses current developments of light-activatable nanoplatforms for modulations of various cellular events including neuromodulations, stem cell monitoring, immunomanipulation, cancer therapy, and other biological target intervention. In summary, the propagation of light-controlled nanomedicine would place a bright prospect for future medicine.
DOI: 10.7150/thno.33888
Rights: © 2019 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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