Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89850
Title: Mapping of γ/δ t cells reveals vδ2+ t cells resistance to senescence
Authors: Xu, Weili
Monaco, Gianni
Wong, Eleanor Huijin
Tan, Wilson Lek Wen
Kared, Hassen
Simoni, Yannick
Tan, Shu Wen
How, Wilson Zhi Yong
Tan, Crystal Tze Ying
Lee, Bernett Teck Kwong
Carbajo, Daniel
K.G., Srinivasan
Low, Ivy Chay Huang
Mok, Esther Wing Hei
Foo, Shihui
Lum, Josephine
Tey, Hong Liang
Tan, Wee Ping
Poidinger, Michael
Newell, Evan
Ng, Tze Pin
Foo, Roger
Akbar, Arne N.
Fülöp, Tamas
Larbi, Anis
Keywords: Cellular Senescence
Aging
DRNTU::Science::Biological sciences::Microbiology::Immunology
Issue Date: 2019
Source: Xu, W., Monaco, G., Wong, E. H., Tan, W. L. W., Kared, H., Simoni, Y., . . . Larbi, A. (2019). Mapping of γ/δ T cells reveals Vδ2+ t cells resistance to senescence. EBioMedicine, 39, 44-58. doi:10.1016/j.ebiom.2018.11.053
Series/Report no.: EBioMedicine
Abstract: Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and their molecular response to stress. Methods: Peripheral blood of young and old donors in Singapore have been used to assess the phenotype, functional capacity, proliferation capacity and gene expression of the various γδ T cell subsets. Peripheral blood mononuclear cells from apheresis cones and young donors have been used to characterise the telomere length, epigenetics profile and DNA damage response of the various γδ T cell subsets phenotype. Findings: Our data shows that peripheral Vδ2+ phenotype, functional capacity (cytokines, cytotoxicity, proliferation) and gene expression profile are specific when compared against all other αβ and γδ T cells in aging. Hallmarks of senescence including telomere length, epigenetic profile and DNA damage response of Vδ2+ also differs against all other αβ and γδ T cells. Interpretation: Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an “innate-like” behavior and are more resilient to the environment as compared to “adaptivelike” Vδ1+ T cells.
URI: https://hdl.handle.net/10356/89850
http://hdl.handle.net/10220/47744
DOI: 10.1016/j.ebiom.2018.11.053
Rights: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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