Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89906
Title: Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis
Authors: Cheng, Catherine Y.
Böhme, Julia
Singhal, Amit
Keywords: Immunity
DRNTU::Science::Medicine::Biomedical engineering
Metabolism
Issue Date: 2018
Source: Cheng, C. Y., Böhme, J., & Singhal, A. Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. Journal of Leukocyte Biology, 103(2), 215-223. doi:10.1189/jlb.4MR0617-226R
Series/Report no.: Journal of Leukocyte Biology
Abstract: A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host‐directed strategies not only accelerate the clearance of pathogens but also have the ability to limit overt inflammation and pathology, which are associated with the tissue damage. Studies have indicated that inflammatory responses are intrinsically linked to cellular metabolism and together drive the fate of many host responses, coupling host survival with the capacity to respond to infectious insult. Metabolic sensors such as mammalian target of rapamycin, AMP‐activated protein kinase, and sirtuin 1 are central regulators of host metabolic alterations and play important roles in immune responses against infections. The present review discusses the functions of AMP‐activated protein kinase and sirtuin 1, with a focus on their role in immune homeostasis and how manipulating the AMP‐activated protein kinase–sirtuin 1 axis with drugs can modulate immunity to tuberculosis.
URI: https://hdl.handle.net/10356/89906
http://hdl.handle.net/10220/47778
ISSN: 0741-5400
DOI: 10.1189/jlb.4MR0617-226R
Rights: © 2017 Society for Leukocyte Biology. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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