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Title: In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others
Authors: Liew, Andy Wen Loong
Zhang, Yilei
Keywords: Pre-vascularization
DRNTU::Engineering::Mechanical engineering
Issue Date: 2017
Source: Liew, A. W. L., & Zhang, Y. (2017). In vitro pre-vascularization strategies for tissue engineered constructs – bioprinting and others. International Journal of Bioprinting, 3(1), 3-17. doi:10.18063/IJB.2017.01.008
Series/Report no.: International Journal of Bioprinting
Abstract: Tissue-engineered products commercially available today have been limited to thin avascular tissue such as skin and cartilage. The fabrication of thicker, more complex tissue still eludes scientists today. One reason for this is the lack of effective techniques to incorporate functional vascular networks within thick tissue constructs. Vascular networks provide cells throughout the tissue with adequate oxygen and nutrients; cells located within thick un-vascularized tissue implants eventually die due to oxygen and nutrient deficiency. Vascularization has been identified as one of the key components in the field of tissue engineering. In order to fabricate biomimetic tissue which accurately recapitulates our native tissue environment, in vitro pre-vascularization strategies need to be developed. In this review, we describe various in vitro vascularization techniques developed recently which employ different technologies such as bioprinting, microfluidics, micropatterning, wire molding, and cell sheet engineering. We describe the fabrication process and unique characteristics of each technique, as well as provide our perspective on the future of the field.
DOI: 10.18063/IJB.2017.01.008
Schools: School of Mechanical and Aerospace Engineering 
Research Centres: Singapore Centre for 3D Printing 
Rights: © 2017 Andy Wen Loong Liew. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons. org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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