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Title: Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease
Authors: Gallart-Palau, Xavier
Lee, Benjamin Sian Teck
Adav, Sunil Shankar
Qian, Jingru
Serra, Aida
Park, Jung Eun
Lai, Mitchell K. P.
Chen, Christopher P.
Kalaria, Raj N.
Sze, Siu Kwan
Keywords: DRNTU::Science::Biological sciences
Alzheimer’s Disease
Cerebrovascular Disease
Issue Date: 2016
Source: Gallart-Palau, X., Lee, B. S. T., Adav, S. S., Qian, J., Serra, A., Park, J. E., . . . Sze, S. K. (2016). Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease. Molecular Brain, 9(1), 27-. doi:10.1186/s13041-016-0205-7
Series/Report no.: Molecular Brain
Abstract: Background: Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer’s disease with cerebrovascular disease (AD + CVD). Results: We detected modulation of several redox proteins in the temporal lobe of AD + CVD subjects, and we observed sex-specific alterations in the white matter (WM) and mitochondria proteomes of female patients. Functional proteomic analysis of AD + CVD brain tissues revealed increased citrullination of arginine and deamidation of glutamine residues of myelin basic protein (MBP) in female which impaired degradation of degenerated MBP and resulted in accumulation of non-functional MBP in WM. Female patients also displayed down-regulation of ATP sub-units and cytochromes, suggesting increased severity of mitochondria impairment in women. Conclusions: Our study demonstrates that gender-linked modulation of white matter and mitochondria proteomes influences neuropathology of the temporal lobe in AD + CVD.
DOI: 10.1186/s13041-016-0205-7
Schools: School of Biological Sciences 
Rights: © 2016 Gallart-Palau et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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