Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/89991
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dc.contributor.authorHoo, Reginaen
dc.contributor.authorZhu, Leien
dc.contributor.authorAmaladoss, Anburajen
dc.contributor.authorMok, Sachelen
dc.contributor.authorNatalang, Ongumaen
dc.contributor.authorLapp, Stacey A.en
dc.contributor.authorHu, Guanganen
dc.contributor.authorLiew, Kingsleyen
dc.contributor.authorGalinski, Mary R.en
dc.contributor.authorBozdech, Zbyneken
dc.contributor.authorPreiser, Peter Raineren
dc.date.accessioned2018-10-29T09:03:46Zen
dc.date.accessioned2019-12-06T17:38:11Z-
dc.date.available2018-10-29T09:03:46Zen
dc.date.available2019-12-06T17:38:11Z-
dc.date.issued2016en
dc.identifier.citationHoo, R., Zhu, L., Amaladoss, A., Mok, S., Natalang, O., Lapp, S. A., . . . Preiser, P. R. (2016). Integrated analysis of the Plasmodium species transcriptome. EBioMedicine, 7(1), 255-266. doi:10.1016/j.ebiom.2016.04.011en
dc.identifier.urihttps://hdl.handle.net/10356/89991-
dc.description.abstractThe genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with critical functional processes. Modeling of the evolutionary relationship based on changes in transcriptional profile reveal a phylogeny pattern of the Plasmodium species that strictly follows its mammalian hosts. In addition, the work shows that transcriptional conserved orthologs represent potential future targets for anti-malaria intervention as they would be expected to carry out key essential functions within the parasites. This work provides an integrated analysis of orthologous transcriptome, which aims to provide insights into the Plasmodium evolution thereby establishing a framework to explore complex pathways and drug discovery in Plasmodium species with broad host range.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent12 p.en
dc.language.isoenen
dc.relation.ispartofseriesEBioMedicineen
dc.rights© 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.subjectDRNTU::Science::Biological sciencesen
dc.subjectComparative Transcriptomicsen
dc.subjectPlasmodium Speciesen
dc.titleIntegrated analysis of the Plasmodium species transcriptomeen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1016/j.ebiom.2016.04.011en
dc.description.versionPublished versionen
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