Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/90052
Title: Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype
Authors: Jakhar, Rekha
Crasta, Karen
Keywords: Senescence
SASP
Science::Medicine
Issue Date: 2019
Source: Jakhar, R., & Crasta, K. (2019). Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype. International Journal of Molecular Sciences, 20(10), 2547-. doi:10.3390/ijms20102547
Series/Report no.: International Journal of Molecular Sciences
Abstract: Communication between cells is quintessential for biological function and cellular homeostasis. Membrane-bound extracellular vesicles known as exosomes play pivotal roles in mediating intercellular communication in tumor microenvironments. These vesicles and exosomes carry and transfer biomolecules such as proteins, lipids and nucleic acids. Here we focus on exosomes secreted from senescent cells. Cellular senescence can alter the microenvironment and influence neighbouring cells via the senescence-associated secretory phenotype (SASP), which consists of factors such as cytokines, chemokines, matrix proteases and growth factors. This review focuses on exosomes as emerging SASP components that can confer pro-tumorigenic effects in pre-malignant recipient cells. This is in addition to their role in carrying SASP factors. Transfer of such exosomal components may potentially lead to cell proliferation, inflammation and chromosomal instability, and consequently cancer initiation. Senescent cells are known to gather in various tissues with age; eliminating senescent cells or blocking the detrimental effects of the SASP has been shown to alleviate multiple age-related phenotypes. Hence, we speculate that a better understanding of the role of exosomes released from senescent cells in the context of cancer biology may have implications for elucidating mechanisms by which aging promotes cancer and other age-related diseases, and how therapeutic resistance is exacerbated with age.
URI: https://hdl.handle.net/10356/90052
http://hdl.handle.net/10220/49392
ISSN: 1661-6596
DOI: 10.3390/ijms20102547
Rights: © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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