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Title: Ultra-sensitive chemical and biological analysis via specialty fibers with built-in microstructured optofluidic channels
Authors: Zhang, Nan
Li, Kaiwei
Cui, Ying
Wu, Zhifang
Shum, Perry Ping
Auguste, Jean-Louis
Dinh, Xuan Quyen
Humbert, Georges
Wei, Lei
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Microfluidic Channel
Issue Date: 2018
Source: Zhang, N., Li, K., Cui, Y., Wu, Z., Shum, P. P., Auguste, J.-L., . . . Wei, L. (2018). Ultra-sensitive chemical and biological analysis via specialty fibers with built-in microstructured optofluidic channels. Lab on a Chip, 18(4), 655-661. doi:10.1039/C7LC01247K
Series/Report no.: Lab on a Chip
Abstract: All-in-fiber optofluidics is an analytical tool that provides enhanced sensing performance with simplified analyzing system design. Currently, its advance is limited either by complicated liquid manipulation and light injection configuration or by low sensitivity resulting from inadequate light–matter interaction. In this work, we design and fabricate a side-channel photonic crystal fiber (SC-PCF) and exploit its versatile sensing capabilities in in-line optofluidic configurations. The built-in microfluidic channel of the SC-PCF enables strong light–matter interaction and easy lateral access of liquid samples in these analytical systems. In addition, the sensing performance of the SC-PCF is demonstrated with methylene blue for absorptive molecular detection and with human cardiac troponin T protein by utilizing a Sagnac interferometry configuration for ultra-sensitive and specific biomolecular specimen detection. Owing to the features of great flexibility and compactness, high-sensitivity to the analyte variation, and efficient liquid manipulation/replacement, the demonstrated SC-PCF offers a generic solution to be adapted to various fiber-waveguide sensors to detect a wide range of analytes in real time, especially for applications from environmental monitoring to biological diagnosis.
ISSN: 1473-0197
DOI: 10.1039/C7LC01247K
Rights: © 2018 The Author(s). All rights reserved. This paper was published by The Royal Society of Chemistry in Lab on a Chip and is made available with permission of The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
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