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Title: Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles
Authors: Nguyen, Thuy-Khanh
Selvanayagam, Ramona
Ho, Kitty K. K.
Chen, Renxun
Kutty, Samuel K.
Rice, Scott A.
Kumar, Naresh
Barraud, Nicolas
Duong, Hien T. T.
Boyer, Cyrille
Keywords: Nitric Oxide
DRNTU::Science::Biological sciences
Issue Date: 2016
Source: Nguyen, T.-K., Selvanayagam, R., Ho, K. K. K., Chen, R., Kutty, S. K., Rice, S. A.,. . . Boyer, C. (2016). Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles. Chemical Science, 7(2), 1016-1027. doi:10.1039/C5SC02769A
Series/Report no.: Chemical Science
Abstract: The rise of hospital-acquired infections, also known as nosocomial infections, is a growing concern in intensive healthcare, causing the death of hundreds of thousands of patients and costing billions of dollars worldwide every year. In addition, a decrease in the effectiveness of antibiotics caused by the emergence of drug resistance in pathogens living in biofilm communities poses a significant threat to our health system. The development of new therapeutic agents is urgently needed to overcome this challenge. We have developed new dual action polymeric nanoparticles capable of storing nitric oxide, which can provoke dispersal of biofilms into an antibiotic susceptible planktonic form, together with the aminoglycoside gentamicin, capable of killing the bacteria. The novelty of this work lies in the attachment of NO-releasing moiety to an existing clinically used drug, gentamicin. The nanoparticles were found to release both agents simultaneously and demonstrated synergistic effects, reducing the viability of Pseudomonas aeruginosa biofilm and planktonic cultures by more than 90% and 95%, respectively, while treatments with antibiotic or nitric oxide alone resulted in less than 20% decrease in biofilm viability.
ISSN: 2041-6520
DOI: 10.1039/C5SC02769A
Rights: © 2016 The Author(s) (published by Royal Society of Chemistry). This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCELSE Journal Articles

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