Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/90265
Title: Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics
Authors: Zhu, Houjuan
Cheng, Penghui
Chen, Peng
Pu, Kanyi
Keywords: DRNTU::Engineering::Chemical engineering
Photodynamic Therapy
Photothermal Therapy
Issue Date: 2018
Source: Zhu, H., Cheng, P., Chen, P., & Pu, K. (2018). Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics. Biomaterials Science, 6(4), 746-765. doi:10.1039/C7BM01210A
Series/Report no.: Biomaterials Science
Abstract: Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue. In contrast to inorganic nanoparticles, near-infrared (NIR) absorbing organic nanoparticles bypass the issue of metal-ion induced toxicity and thus are generally considered to be more biocompatible. Moreover, with the guidance of different kinds of imaging methods, the efficacy of cancer phototherapy based on organic nanoparticles has shown to be optimizable. In this review, we summarize the synthesis and application of NIR-absorbing organic nanoparticles as phototherapeutic nanoagents for cancer phototherapy. The chemistry, optical properties and therapeutic efficacies of organic nanoparticles are firstly described. Their phototherapy applications are then surveyed in terms of therapeutic modalities, which include PTT, PDT and PTT/PDT combined therapy. Finally, the present challenges and potential of imaging guided PTT/PDT are discussed.
URI: https://hdl.handle.net/10356/90265
http://hdl.handle.net/10220/48503
ISSN: 2047-4830
DOI: 10.1039/C7BM01210A
Rights: © 2018 The Author(s). All rights reserved. This paper was published by The Royal Society of Chemistry in Biomaterials Science and is made available with permission of The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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