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Title: Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications
Authors: Chamundeswari, Vidya Narasimhan
Lui, Yuan Siang
Chuah, Yon Jin
Tan, Jing Shi
Wang, Dong-An
Loo, Joachim Say Chye
Keywords: DRNTU::Engineering::Materials
Spongy Scaffold
Biodegradable Polymers
Issue Date: 2017
Source: Chamundeswari, V. N., Lui, Y. S., Chuah, Y. J., Tan, J. S., Wang, D.-A., & Loo, J. S. C. (2018). Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications. Biomedical Materials, 13(1), 015019-. doi:10.1088/1748-605X/aa8bcd
Series/Report no.: Biomedical Materials
Abstract: Tissue engineering (TE) is envisaged to play a vital role in improving quality of life by restoring, maintaining or enhancing tissue and organ functions. TE scaffolds that are two-dimensional in structure suffer from undesirable issues, such as pore blockage, and do not closely mimic the native extra-cellular matrix in tissues. Significant efforts have therefore been channeled to fabricate three-dimensional (3D) scaffolds using various techniques, especially electrospinning. In this study, we propose a modified one-step electrospinning process to arrive at a 3D scaffold with highly interconnected pores. Using a blend of poly (L-lactide)/polycaprolactone/poly (ethylene oxide), this mechanically viable, sponge-like 3D scaffold exhibited sufficiently large pores and enabled cell penetration beyond 500 μm. Dexamethasone (Dex) was loaded into the fibers and a sustained drug release was achieved. Further, the potential of this Dex-loaded 3D scaffold was evaluated for upregulation of osteogenic genes with mesenchymal stem cells. The as-produced Dex-loaded 3D scaffold possesses a unique intertwined sub-micron fibrous morphology that can be tailored for use in bone tissue engineering and beyond.
ISSN: 1748-6041
DOI: 10.1088/1748-605X/aa8bcd
Schools: School of Chemical and Biomedical Engineering 
School of Materials Science & Engineering 
Research Centres: Singapore Centre for Environmental Life Sciences and Engineering 
Rights: © 2017 IOP Publishing Ltd. All rights reserved. This is an author-created, un-copyedited version of an article accepted for publication in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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