Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChamundeswari, Vidya Narasimhanen
dc.contributor.authorLui, Yuan Siangen
dc.contributor.authorChuah, Yon Jinen
dc.contributor.authorTan, Jing Shien
dc.contributor.authorWang, Dong-Anen
dc.contributor.authorLoo, Joachim Say Chyeen
dc.identifier.citationChamundeswari, V. N., Lui, Y. S., Chuah, Y. J., Tan, J. S., Wang, D.-A., & Loo, J. S. C. (2018). Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications. Biomedical Materials, 13(1), 015019-. doi:10.1088/1748-605X/aa8bcden
dc.description.abstractTissue engineering (TE) is envisaged to play a vital role in improving quality of life by restoring, maintaining or enhancing tissue and organ functions. TE scaffolds that are two-dimensional in structure suffer from undesirable issues, such as pore blockage, and do not closely mimic the native extra-cellular matrix in tissues. Significant efforts have therefore been channeled to fabricate three-dimensional (3D) scaffolds using various techniques, especially electrospinning. In this study, we propose a modified one-step electrospinning process to arrive at a 3D scaffold with highly interconnected pores. Using a blend of poly (L-lactide)/polycaprolactone/poly (ethylene oxide), this mechanically viable, sponge-like 3D scaffold exhibited sufficiently large pores and enabled cell penetration beyond 500 μm. Dexamethasone (Dex) was loaded into the fibers and a sustained drug release was achieved. Further, the potential of this Dex-loaded 3D scaffold was evaluated for upregulation of osteogenic genes with mesenchymal stem cells. The as-produced Dex-loaded 3D scaffold possesses a unique intertwined sub-micron fibrous morphology that can be tailored for use in bone tissue engineering and beyond.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent31 p.en
dc.relation.ispartofseriesBiomedical Materialsen
dc.rights© 2017 IOP Publishing Ltd. All rights reserved. This is an author-created, un-copyedited version of an article accepted for publication in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at
dc.subjectSpongy Scaffolden
dc.subjectBiodegradable Polymersen
dc.titleSustained releasing sponge-like 3D scaffolds for bone tissue engineering applicationsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen
dc.description.versionAccepted versionen
item.fulltextWith Fulltext-
Appears in Collections:MSE Journal Articles
Files in This Item:
File Description SizeFormat 
Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications.pdf1.36 MBAdobe PDFThumbnail

Citations 20

Updated on Jul 5, 2022

Web of ScienceTM
Citations 20

Updated on Jul 6, 2022

Page view(s)

Updated on Sep 28, 2022

Download(s) 50

Updated on Sep 28, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.