Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/92353
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dc.contributor.authorChamundeswari, Vidya Narasimhanen
dc.contributor.authorLui, Yuan Siangen
dc.contributor.authorChuah, Yon Jinen
dc.contributor.authorTan, Jing Shien
dc.contributor.authorWang, Dong-Anen
dc.contributor.authorLoo, Joachim Say Chyeen
dc.date.accessioned2019-06-03T04:04:04Zen
dc.date.accessioned2019-12-06T18:21:49Z-
dc.date.available2019-06-03T04:04:04Zen
dc.date.available2019-12-06T18:21:49Z-
dc.date.issued2017en
dc.identifier.citationChamundeswari, V. N., Lui, Y. S., Chuah, Y. J., Tan, J. S., Wang, D.-A., & Loo, J. S. C. (2018). Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications. Biomedical Materials, 13(1), 015019-. doi:10.1088/1748-605X/aa8bcden
dc.identifier.issn1748-6041en
dc.identifier.urihttps://hdl.handle.net/10356/92353-
dc.description.abstractTissue engineering (TE) is envisaged to play a vital role in improving quality of life by restoring, maintaining or enhancing tissue and organ functions. TE scaffolds that are two-dimensional in structure suffer from undesirable issues, such as pore blockage, and do not closely mimic the native extra-cellular matrix in tissues. Significant efforts have therefore been channeled to fabricate three-dimensional (3D) scaffolds using various techniques, especially electrospinning. In this study, we propose a modified one-step electrospinning process to arrive at a 3D scaffold with highly interconnected pores. Using a blend of poly (L-lactide)/polycaprolactone/poly (ethylene oxide), this mechanically viable, sponge-like 3D scaffold exhibited sufficiently large pores and enabled cell penetration beyond 500 μm. Dexamethasone (Dex) was loaded into the fibers and a sustained drug release was achieved. Further, the potential of this Dex-loaded 3D scaffold was evaluated for upregulation of osteogenic genes with mesenchymal stem cells. The as-produced Dex-loaded 3D scaffold possesses a unique intertwined sub-micron fibrous morphology that can be tailored for use in bone tissue engineering and beyond.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent31 p.en
dc.language.isoenen
dc.relation.ispartofseriesBiomedical Materialsen
dc.rights© 2017 IOP Publishing Ltd. All rights reserved. This is an author-created, un-copyedited version of an article accepted for publication in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://doi.org/10.1088/1748-605X/aa8bcden
dc.subjectDRNTU::Engineering::Materialsen
dc.subjectSpongy Scaffolden
dc.subjectBiodegradable Polymersen
dc.titleSustained releasing sponge-like 3D scaffolds for bone tissue engineering applicationsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen
dc.identifier.doi10.1088/1748-605X/aa8bcden
dc.description.versionAccepted versionen
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