Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/93147
Title: Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores
Authors: Mundargi, Raghavendra C.
Tan, Ee-Lin
Seo, Jeongeun
Cho, Nam-Joon
Keywords: Lycopodium clavatum
Spores
Microencapsulation
5-Fluorouracil
Controlled release
Issue Date: 2016
Source: Mundargi, R. C., Tan, E.-L., Seo, J., & Cho, N.-J. (2016). Encapsulation and controlled release formulations of 5-fluorouracil from natural Lycopodium clavatum spores. Journal of Industrial and Engineering Chemistry, 36, 102-108.
Series/Report no.: Journal of Industrial And Engineering Chemistry
Abstract: Cost effective, uniform-size multiparticulate formulations of the chemotherapeutic agent 5-fluorouracil (5-FU) loaded in natural Lycopodium clavatum spores were developed by three different encapsulation techniques: passive, compression and vacuum loading. The surface morphology, and micromeritic properties of 5-FU spore formulations were characterized by scanning electron microscopy and dynamic image particle analysis, respectively. The encapsulation efficiency of spores by vacuum-assisted loading was higher (49%) compared to passive and compression loading techniques. The vacuum-loaded formulation was selected for further development with a Eudragit RS 100 (EUD) coating that enabled controlled 5-FU release in simulated gastric (pH 1.2) and intestinal (pH 7.4) conditions. The surface morphology analysis after EUD coating at two different EUD concentrations (2.5% w/v and 10% w/v) indicates that a thin, conformal layer of EUD was deposited on the spore surface. The in-vitro release of 5-FU from coated spores exhibited a slower release profile compared to uncoated spores, and was extended for up to 30 h in simulated gastrointestinal conditions. Collectively, the findings demonstrate that EUD coated 5-FU loaded natural L. clavatum spores provide a controlled release formulation that would aid treatment options against gastrointestinal cancer and other related maladies.
URI: https://hdl.handle.net/10356/93147
http://hdl.handle.net/10220/40599
ISSN: 1226-086X
DOI: 10.1016/j.jiec.2016.01.022
Rights: © 2016 The Korean Society of Industrial and Engineering Chemistry.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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