Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHajduk, Philip J.en
dc.contributor.authorPetros, Andrew M.en
dc.contributor.authorOlejniczak, Edward T.en
dc.contributor.authorMeadows, Robert P.en
dc.contributor.authorFesik, Stephen W.en
dc.contributor.authorYoon, Ho Supen
dc.identifier.citationYoon, H. S., Hajduk, P. J., Petros, A. M., Olejniczak, E. T., Meadows, R. P., & Fesik, S. W. (1994). Solution structure of a pleckstrin-homology domain. Nature, 369, 672-675.en
dc.description.abstractPLECKSTRIN1, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins2–5. These conserved sequences, termed pleckstrin-homology (PH) domains, are thought to be involved in signal transduction. But the details of the function and binding partners of the PH domains have not been characterized. Here we report the solution structure of the N-terminal pleckstrin-homology domain of pleckstrin determined using heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. The structure consists of an up-and-down β-barrel of seven antiparallel β-strands and a C-terminal amphiphilic α-helix that caps one end of the barrel. The overall topology of the domain is similar to that of the retinol-binding protein family of structures6–10.en
dc.format.extent10 p.en
dc.rights© 1994 Nature Publishing Group. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature, Nature Publishing Group. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at:
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleSolution structure of a pleckstrin-homology domainen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionAccepted versionen
item.fulltextWith Fulltext-
Appears in Collections:SBS Journal Articles
Files in This Item:
File Description SizeFormat 
46. Solution structure of a pleckstrin-homology domain.pdf477.53 kBAdobe PDFThumbnail

Citations 5

Updated on May 21, 2023

Web of ScienceTM
Citations 1

Updated on May 29, 2023

Page view(s) 5

Updated on May 30, 2023

Download(s) 5

Updated on May 30, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.