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Title: Reliable addition of reagents into microfluidic droplets
Authors: Sivasamy Jayaprakash
Chim, Yong Cai
Wong, Teck Neng
Nguyen, Nam-Trung
Yobas, Levent
Keywords: DRNTU::Engineering::Mechanical engineering
Issue Date: 2010
Source: Sivasamy, J., Chim, Y. C., Wong,T. N., Nguyen, N. T., & Yobas, L. (2009). Reliable addition of reagents into microfluidic droplets. Microfluidics and Nanofluidics, 8(3), 409-416.
Series/Report no.: Microfluidics and nanofluidics
Abstract: This article reports a design that reliably adds reagents into droplets by exploiting the physics of fluid flow at a T-junction in the microchannel. An expanded section right after the T-junction enhances merging of a stream with a droplet, eliminates the drawbacks such as extra droplet formation and long mixing time. The expanded section reduces the pressure buildup at the T-junction and minimizes the tendency to form extra droplets; plays the role in creating low Laplace pressure jump across the interface of the droplet forming from the T-junction which reduces the probability of forming extra droplet in the merging process; provides space for droplet coalescence if there is an extra droplet due to droplet break-up before merging. In this design, after merging, the reactants are in axial arrangement inside the droplets which lead to faster mixing. Reliable addition of reagent to the droplets happens for the combination of flow rates in a broad range from 25 to 250 μl/h, for both DI water (Q DI) and fluorescent (Q fluo) streams.
DOI: 10.1007/s10404-009-0531-5
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2009 Springer-Verlag. This is the author created version of a work that has been peer reviewed and accepted for publication by Microfluidics and Nanofluidics, Springer-Verlag. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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