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Title: CMOS high density electrical impedance biosensor array for tumor cell detection
Authors: Chandran, Jegatha
Chen, Yu
Wong, Chee Chung
Pui, Tze Sian
Nadipalli, Revanth
Weerasekera, Roshan
Yu, Hao
Rahman, Abdur Rub Abdur
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Chen, Y., Wong, C. C., Pui, T. S., Nadipalli, R., Weerasekera, R., Chandran, J., et al. (2012). CMOS high density electrical impedance biosensor array for tumor cell detection. Sensors and actuators B : chemical, 173, 903-907.
Series/Report no.: Sensors and actuators B : chemical
Abstract: We present a high-throughput label-free electrical-impedance spectroscopy (EIS) platform composed of a 96 × 96 microelectrode array for counting and analysis of breast tumor cells (MCF-7). These Auelectrodes are densely packed within a 3.5 mm × 3.5 mm interrogation region. Each Au-electrode has an edge-length of 25 μm designed to detect single tumor cell by electrical impedance spectroscopy. The detected signal is read out via an integrated circuit (IC) of addressable electrode-selection-switch array manufactured with 0.18μm CMOS technology. The independently addressable microelectrode array is integrated onto a printed circuit board (PCB) containing associated circuitry for electrode switching and readout. MCF-7 cells were dispensed onto the chip surface and EIS measurements were recorded before and after the cell dispensation. On an average 20% increase in impedance was found associated with cell occupancy on the electrode surface. A positive correlation was observed between cell detection with optical microscopy and with electrical scanning.
ISSN: 09254005
DOI: 10.1016/j.snb.2012.07.024
Rights: © 2012 Elsevier B. V. This is the author created version of a work that has been peer reviewed and accepted for publication by Sensors and actuators B: chemical, Elsevier B. V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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