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https://hdl.handle.net/10356/94527
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Satyanarayanajois, Seetharama D. | en |
dc.contributor.author | Giddu, Sumana | en |
dc.contributor.author | Subramanian, Vivekanandan | en |
dc.contributor.author | Yoon, Ho Sup | en |
dc.date.accessioned | 2012-01-26T01:34:47Z | en |
dc.date.accessioned | 2019-12-06T18:57:27Z | - |
dc.date.available | 2012-01-26T01:34:47Z | en |
dc.date.available | 2019-12-06T18:57:27Z | - |
dc.date.copyright | 2009 | en |
dc.date.issued | 2009 | en |
dc.identifier.citation | Giddu, S., Subramanian, V., Yoon, H. S., & Satyanarayanajois, S. D. (2009). Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn Constraint. Journal of Medicinal Chemistry, 52(3), 726-736. | en |
dc.identifier.uri | https://hdl.handle.net/10356/94527 | - |
dc.description.abstract | The CD2−CD58 interaction in immune regulation and disease pathology has provided new targets for developing potential immunosuppressive agents. In the present study, we report the introduction of constraints to generate β-hairpin structures from the strand sequences of CD2 protein. The β-hairpin structures were induced in the designed peptides by introducing Pro-Gly sequences in the peptides. Results from NMR and MD simulation indicated that the peptides exhibited β-turn structure at the X-Pro-Gly-Y sequence and formed the β-hairpin structure in solution. The ability of these peptides to inhibit cell adhesion was evaluated by two cell adhesion assays. Among the peptides studied (1−4) (P1−P4), peptides 2−4 were able to inhibit cell adhesion between Jurkat cells and SRBC nearly 50% at 180 μM, and 80% inhibition between Jurkat cells and Caco-2 cells was seen at 90 μM. Peptide 1 did not show significant inhibition activity compared to control. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Journal of medicinal Chemistry | en |
dc.rights | © 2009 American Chemical Society. | en |
dc.subject | DRNTU::Science::Biological sciences::Molecular biology | en |
dc.title | Design of β-hairpin peptides for modulation of cell adhesion by β-turn constraint | en |
dc.type | Journal Article | en |
dc.contributor.school | School of Biological Sciences | en |
dc.identifier.doi | 10.1021/jm8008212 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | SBS Journal Articles |
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