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Title: Cyclotides : a novel class of natural antibiotics
Authors: Ang, Koon Hwee
Keywords: Cyclotides
Issue Date: 2011
Source: Ang, K. H. (2011, March). Cyclotides – a novel class of natural antibiotics. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.
Abstract: Cyclotides are circular plant proteins that are approximately 30 amino acids long and have high heat and enzymatic stability. Their N- and C- termini are joined together to form a continuous cyclic conformation. The three-dimensional structure is stabilized by three disulphide bonds arranged in a cystine knot. Cyclotides are known to be antimicrobial, hemolytic, immunomodulating and anti-cancer, thus forming the basis of medicinal plants against various diseases. Bacterial drug resistance is a major concern, and there is an urgent need to discover novel antibiotics. In this project, we are looking at the antibacterial function of cyclotides extracted from a locally grown plant, Clitoria ternatea which belongs to the Fabaceae family. My results show that cyclotides are potent antimicrobial agents and exhibit synergy with conventional antibiotics. [Peer Assessment Review]
Rights: © 2011 The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:URECA Posters

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