Modify the "vault" for a better drug delivery capsule

Abstract

The vault is a protein naturally occurring in most eukaryotic-cell organisms, except for fruit fly, a type of worm and yeast. It is most frequently suggested with some transportation function within the cell. The key components in the vault we are manipulating are the major vault proteins (MVPs) (green) and the minimal interacting domain (mINT) (red). Naturally the vault can disassemble under a pH lower than 4. The vault can be a good drug delivery capsule, due to its large capacity and bio-compatibility. Therapeutic molecules can be fused to mINT and easily enclosed into the vault shell. [Peer Assessment Review]