Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/95153
Title: Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique
Authors: Kumar, R.
Lu, Y. W.
Xu, Jinling
Khor, Khiam Aik
Chen, William Wei Ning
Keywords: DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2007
Source: Xu, J. L., Khor, K. A., Lu, Y. W., Chen, W. N. W., & Kumar, R. (2007). Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique. Journal of biomedical materials research part B : applied biomaterials, 84B(1), 224-230.
Series/Report no.: Journal of biomedical materials research Part B: applied biomaterials
Abstract: This study investigated the osteoblast behaviors on various hydroxyapatite based biomaterials that were consolidated at 1100°C for 3 min by a spark plasma sintering technique. The osteoblasts from human fetal osteoblast cell line were cultured in the medium on the various biomaterials surfaces (HA, RF21, 1SiHA, and 5SiHA) to assess the cell morphology and proliferation as well as cell differentiation (alkaline phosphatase activity). Moreover, the bone -carboxyglutamic protein or osteocalcin in the medium were determined at different periods of culture. The present results indicated that the amount of osteocalcin in the medium decreased during the periods of culture. The highest osteocalcin production obtained from the biomaterial 5SiHA after cell culture for 2 days demonstrated that the presence of silica in the biomaterials enhanced the cell differentiation by the rapid release of silicate and calcium ions.
URI: https://hdl.handle.net/10356/95153
http://hdl.handle.net/10220/8421
ISSN: 1552-4981
DOI: 10.1002/jbm.b.30864
Rights: © 2007 Wiley Periodicals, Inc.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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