Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/95589
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dc.contributor.authorZhang, Juanen
dc.contributor.authorWang, Lihuaen
dc.contributor.authorPan, Dunen
dc.contributor.authorSong, Shipingen
dc.contributor.authorBoey, Freddy Yin Chiangen
dc.contributor.authorZhang, Huaen
dc.contributor.authorFan, Chunhaien
dc.date.accessioned2012-09-24T01:00:02Zen
dc.date.accessioned2019-12-06T19:17:56Z-
dc.date.available2012-09-24T01:00:02Zen
dc.date.available2019-12-06T19:17:56Z-
dc.date.copyright2008en
dc.date.issued2008en
dc.identifier.citationZhang, J., Wang, L., Pan, D., Song, S., Boey, F. Y. C., Zhang, H., et al. (2008). Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. Small, 4(8), 1196-1200.en
dc.identifier.issn1613-6829en
dc.identifier.urihttps://hdl.handle.net/10356/95589-
dc.description.abstractA novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles into the intact aptamer tertiary structure in the presence of the specific target. AuNPs can effectively differentiate between these two states via their characteristic surface-plasmon resonance-based color change. Using this method, cocaine in the low-micromolar range is selectively detected within minutes. This strategy is also shown to be generic and applicable to the detection of several other small-molecule targets.en
dc.language.isoenen
dc.relation.ispartofseriesSmallen
dc.rights© 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.subjectDRNTU::Engineering::Materialsen
dc.titleVisual cocaine detection with gold nanoparticles and rationally engineered aptamer structuresen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.identifier.doi10.1002/smll.200800057en
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:MSE Journal Articles

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