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Title: Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures
Authors: Zhang, Juan
Wang, Lihua
Pan, Dun
Song, Shiping
Boey, Freddy Yin Chiang
Zhang, Hua
Fan, Chunhai
Keywords: DRNTU::Engineering::Materials
Issue Date: 2008
Source: Zhang, J., Wang, L., Pan, D., Song, S., Boey, F. Y. C., Zhang, H., et al. (2008). Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. Small, 4(8), 1196-1200.
Series/Report no.: Small
Abstract: A novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles into the intact aptamer tertiary structure in the presence of the specific target. AuNPs can effectively differentiate between these two states via their characteristic surface-plasmon resonance-based color change. Using this method, cocaine in the low-micromolar range is selectively detected within minutes. This strategy is also shown to be generic and applicable to the detection of several other small-molecule targets.
ISSN: 1613-6829
DOI: 10.1002/smll.200800057
Schools: School of Materials Science & Engineering 
Rights: © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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