Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/95768
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dc.contributor.authorLiu, Qianen
dc.contributor.authorKwoh, Chee Keongen
dc.contributor.authorHoi, Steven Chu Hongen
dc.date.accessioned2013-07-22T03:19:21Zen
dc.date.accessioned2019-12-06T19:21:07Z-
dc.date.available2013-07-22T03:19:21Zen
dc.date.available2019-12-06T19:21:07Z-
dc.date.copyright2013en
dc.date.issued2013en
dc.identifier.citationLiu, Q., Kwoh, C. K., & Hoi, S. C. H. (2013). Beta Atomic Contacts: Identifying Critical Specific Contacts in Protein Binding Interfaces. PLoS ONE, 8(4), e59737.en
dc.identifier.issn1932-6203en
dc.identifier.urihttps://hdl.handle.net/10356/95768-
dc.identifier.urihttp://hdl.handle.net/10220/11932en
dc.description.abstractSpecific binding between proteins plays a crucial role in molecular functions and biological processes. Protein binding interfaces and their atomic contacts are typically defined by simple criteria, such as distance-based definitions that only use some threshold of spatial distance in previous studies. These definitions neglect the nearby atomic organization of contact atoms, and thus detect predominant contacts which are interrupted by other atoms. It is questionable whether such kinds of interrupted contacts are as important as other contacts in protein binding. To tackle this challenge, we propose a new definition called beta (β) atomic contacts. Our definition, founded on the β-skeletons in computational geometry, requires that there is no other atom in the contact spheres defined by two contact atoms; this sphere is similar to the van der Waals spheres of atoms. The statistical analysis on a large dataset shows that β contacts are only a small fraction of conventional distance-based contacts. To empirically quantify the importance of β contacts, we design βACV, an SVM classifier with β contacts as input, to classify homodimers from crystal packing. We found that our βACV is able to achieve the state-of-the-art classification performance superior to SVM classifiers with distance-based contacts as input. Our βACV also outperforms several existing methods when being evaluated on several datasets in previous works. The promising empirical performance suggests that β contacts can truly identify critical specific contacts in protein binding interfaces. β contacts thus provide a new model for more precise description of atomic organization in protein quaternary structures than distance-based contacts.en
dc.language.isoenen
dc.relation.ispartofseriesPLoS ONEen
dc.rights© 2013 The Authors. This paper was published in PLoS ONE and is made available as an electronic reprint (preprint) with permission of The Authors. The paper can be found at the following official DOI: [http://dx.doi.org/10.1371/journal.pone.0059737]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en
dc.subjectDRNTU::Engineering::Computer science and engineeringen
dc.titleBeta atomic contacts : identifying critical specific contacts in protein binding interfacesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Computer Engineeringen
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0059737en
dc.description.versionPublished versionen
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