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Title: The leucocyte β2 (CD18) integrins : the structure, functional regulation and signalling properties
Authors: Tan, Suet Mien
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Tan, S.-M. (2012). The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Bioscience Reports, 32(3), 241-269.
Series/Report no.: Bioscience reports
Abstract: Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is dependent on cell adhesion molecules. The integrins are a family of heterodimeric transmembrane cell adhesion molecules that are also signalling receptors. They are involved in many biological processes, including the development of metazoans, immunity, haemostasis, wound healing and cell survival, proliferation and differentiation. The leucocyte-restricted β2 integrins comprise four members, namely αLβ2, αMβ2, αXβ2 and αDβ2, which are required for a functional immune system. In this paper, the structure, functional regulation and signalling properties of these integrins are reviewed.
ISSN: 0144-8463
DOI: 10.1042/BSR20110101
Rights: © The Authors Journal compilation. © 2012 Biochemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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