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Title: Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties
Authors: Khung, Yit-Lung
Bastari, Kelsen
Cho, Xing Ling
Yee, Wu Aik
Loo, Say Chye Joachim
Issue Date: 2012
Source: Khung, Y. L., Bastari, K., Cho, X. L., Yee, W. A., & Loo, S. C. J. (2012). Designing calcium phosphate-based bifunctional nanocapsules with bone-targeting properties. Journal of nanoparticle research, 14(6).
Series/Report no.: Journal of nanoparticle research
Abstract: Using sodium dodecyl sulphate micelles as template, hollow-cored calcium phosphate nanocapsules were produced. The surfaces of the nanocapsule were subsequently silanised by a polyethylene glycol (PEG)-based silane with an N-hydroxysuccinimide ester end groups which permits for further attachment with bisphosphonates (BP). Characterisations of these nanocapsules were investigated using Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy, Fourier Transform Infra-Red Spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Dynamic Light Scattering. To further validate the bone-targeting potential, dentine discs were incubated with these functionalised nanocapsules. FESEM analysis showed that these surface-modified nanocapsules would bind strongly to dentine surfaces compared to non-functionalised nanocapsules. We envisage that respective components would give this construct a bifunctional attribute, whereby (1) the shell of the calcium phosphate nanocapsule would serve as biocompatible coating aiding in gradual osteoconduction, while (2) surface BP moieties, acting as targeting ligands, would provide the bone-targeting potential of these calcium phosphate nanocapsules.
ISSN: 1572-896X
DOI: 10.1007/s11051-012-0911-8
Rights: © 2012 Springer Science+Business Media B.V.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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