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Title: Direct and stereoselective synthesis of 1,3-cis-3-arylsulphonaminodeoxydisaccharides and oligosaccharides
Authors: Ding, Feiqing
William, Ronny
Cai, Shuting
Ma, Jimei
Liu, Xue-Wei
Issue Date: 2012
Source: Ding, F., William, R., Cai, S., Ma, J., & Liu, X.-W. (2012). Direct and Stereoselective Synthesis of 1,3- cis -3- Arylsulphonaminodeoxydisaccharides and Oligosaccharides . The Journal of Organic Chemistry, 77(12), 5245-5254.
Series/Report no.: The journal of organic chemistry
Abstract: The 3-aminoglycosides are ubiquitous in biologically important classes of glycoconjugates and naturally occurring oligosaccharides. Despite the rapid growth in the development of synthetic method of 3-amino glycosides, the current state-of-the art suffers from limited substrate scope, low yields, long reaction times, and anomeric mixtures. This work presents a novel direct method for the synthesis of 1,3-cis-3-arylsulphonaminodeoxydisaccharides and oligosaccharides via α-selective glycosylation and hydroamination of glycal in a one-pot manner. This efficient multicomponent reaction methodology provides ready access to 1,3-cis-3-arylsulphonaminodeoxydisaccharides and oligosaccharides and allows derivatization by variation of each component.
DOI: 10.1021/jo300791v
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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