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|Title:||Silver acetate catalyzed hydroamination of 1-(2-(Sulfonylamino)phenyl)prop-2-yn-1-ols to (Z)-2-methylene-1-sulfonylindolin-3-ols||Authors:||Susanti, Dewi
Kusuma, Jeffrey Antonius
Chan, Philip Wai Hong
|Keywords:||DRNTU::Science::Chemistry::Organic chemistry||Issue Date:||2012||Source:||Susanti, D., Koh, F., Kusuma, J. A., Kothandaraman, P., & Chan, P. W. H. (2012). Silver acetate catalyzed hydroamination of 1-(2-(Sulfonylamino)phenyl)prop-2-yn-1-ols to (Z)-2-methylene-1-sulfonylindolin-3-ols. The journal of organic chemistry, 77(17), 7166-7175.||Series/Report no.:||The journal of organic chemistry||Abstract:||A method to prepare (Z)-2-methylene-1-sulfonylindolin-3-ols efficiently that relies on silver acetate catalyzed hydroamination of 1-(2-(sulfonylamino)phenyl)prop-2-yn-1-ols is reported. The reactions proceed rapidly at room temperature with catalyst loadings as low as 1 mol % under conditions that did not require the exclusion of air or moisture. The utility of this N-heterocyclic ring-forming strategy as a synthetic tool that makes use of unsaturated alcohols was exemplified by the conversion of the (Z)-2-methylene-1-sulfonylindolin-3-ol to examples of other members of the indole family of compounds.||URI:||https://hdl.handle.net/10356/96164
|DOI:||10.1021/jo301198z||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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